No, officially GTA San Andreas is a single-player game. there are no GTA Online features in the Definitive edition and do not have any type of multiplayer options.
if you want to play multiplayer, you can play GTA 5 Game if you have a compatible device. In the GTA game series, GTA 5 is the best multiplayer game.
GTA san Andreas Definitive edition is the latest version of the GTA san Andreas game but it was not released with an online feature because it did not make sense in the old game, that’s why the Rockstar company did not release it with a multiplayer option. In old GTA san Andreas, there is no direct play multiplayer option but there is a co-op location , when you go there, after doing some simple steps, two payers can play GTA san Andreas.
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Direct play multiplayer option is not available, but there is a Co-op multiplayer option.
No, only a single player can play in the old GTA san Andreas as well as in New GTA San Andreas Game.
Yes, inside the game, there are some locations, when you go there, 2 players can play the GTA san Andreas game, if you are not getting that option then you can also make it available using mods.